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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -COMT, NT (COMT, Catechol O-methyltransferase)

Anti -COMT, NT (COMT, Catechol O-methyltransferase)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Catalog #030887
ApplicationsSuitable for use in Western Blot, ELISA.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100~400
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No630CT1.7.1
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid, crude ascites with 0.09% sodium azide.
PurityAscites
ImmunogenCOMT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COMT.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCOMT, Catechol O-methyltransferase


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