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Anti -DHCR7 (DHCR7, D7SR, 7-dehydrocholesterol reductase, Putative sterol reductase SR-2, Sterol Delta(7)-reductase)
Anti -DHCR7 (DHCR7, D7SR, 7-dehydrocholesterol reductase, Putative sterol reductase SR-2,
Sterol Delta(7)-reductase)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
E B |
|
| This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein. | | | Catalog # | 030913 | | Applications | Suitable for use in Western Blot, ELISA. | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:100~1600 | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgM | | Clone No | 502CT5.1.1 | | Host | Mouse | | Source | Human | | Concentration | Crude ascites | | Form | Supplied as a liquid, crude ascites with 0.09% sodium azide. | | Purity | Ascites | | Immunogen | Purified His-tagged DHCR7 protein (fragment). | | Specificity | Human, rat | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | DHCR7, D7SR, 7-dehydrocholesterol reductase, Putative sterol reductase SR-2, Sterol Delta(7)-reductase |
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