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You are here:Home » Antibodies » Abs to HLA » Anti -HLA-A(ID) (HLA-A, HLAA, HLA class I histocompatibility antigen, A-3 alpha chain, MHC class I antigen A*3)

Anti -HLA-A(ID) (HLA-A, HLAA, HLA class I histocompatibility antigen, A-3 alpha chain, MHC
class I antigen A*3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
Catalog #031022
ApplicationsSuitable for use in Western Blot, ELISA.
Recommended DilutionELISA: 1:1000
Western Blot: 1:100~250
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No7G7F9
HostMouse
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenHLA-A antibody is generated from mouse immunized with a KLH conjugated synthetic peptide selected from the Center region of human HLA-A.
SpecificityMouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesHLA-A, HLAA, HLA class I histocompatibility antigen, A-3 alpha chain, MHC class I antigen A*3


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