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You are here:Home » Antibodies » Abs to Notch Proteins » Anti -Notch3, CT (Notch homolog 3, Drosophila, hN3, CASIL, CADASIL)

Anti -Notch3, CT (Notch homolog 3, Drosophila, hN3, CASIL, CADASIL)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].
Catalog #031161
ApplicationsSuitable for use in Western Blot, ELISA.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100~1600
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No487CT6.9.2
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid, crude ascites with 0.09% sodium azide.
PurityAscites
ImmunogenNOTCH3 Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from the C-term region of human NOTCH3.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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