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You are here:Home » Antibodies » Antibodies-Myelin » Anti -PIp1, ID (Proteolipid protein1)

Anti -PIp1, ID (Proteolipid protein1)


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Clone Host Grade Applications
Monoclonal Mouse Purified E B
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Proteolipid protein (Plp) gene mutation in rodents causes severe CNS dysmyelination, early death, and lethal hypoxic ventilatory depression (Miller et al. 2004). Myelin proteolipid protein (PLP) is the major protein in CNS myelin, accounting for 50% of myelin-associated proteins in the central nervous system. Mutations in the Plp gene, which are X-linked, have been found in rodents, such as the myelin deficient (MD) rat, and the myelin synthesis deficient mouse (Plpmsd). These mutations cause severe dysmyelination in the CNS, associated with oligodendrocyte death and non-myelinated or poorly myelinated axons, as well as abnormal axoglial junctions (Dentinger et al. 1982; Rosenbluth 1987). Most rodents with mutations in the Plp gene develop tremors, ataxia, and seizures in the second week of life, and early death by postnatal day (p) 2123. (Knapp 1996; Garbern et al. 1999; Yool et al. 2000). Plp mutations in humans are associated with a leukoencephalopathy, Pelizaeus-Merzbacher disease, which bears many pathophysiologic similarities to the rodents with Plp mutations (Boulloche and Aicardi 1986). The mechanisms by which mutations in the Plp gene cause a complex and potentially fatal leukoencephalopathy are incompletely understood.
Catalog #031197
ApplicationsSuitable for use in Western Blot, ELISA.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100~500
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No538CT16.5.4
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenRAT PIp1 Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from human RAT PIp1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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