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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -RUVBL1 (RUVBL1, INO80H, NMP238, TIP49, TIP49A, RuvB-like 1, 49kD TATA box-binding protein-interacting protein, 54kD erythrocyte cytosolic protein, INO80 complex subunit H, Nuclear matrix protein 238, Pontin 52, TIP49a, TIP60-associated protein 54-alpha)

Anti -RUVBL1 (RUVBL1, INO80H, NMP238, TIP49, TIP49A, RuvB-like 1, 49kD TATA box-binding
protein-interacting protein, 54kD erythrocyte cytosolic protein, INO80 complex subunit H,
Nuclear matrix protein 238, Pontin 52, TIP49a, TIP60-associated protein 54-alpha)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation.
Catalog #031232
ApplicationsSuitable for use in Western Blot, ELISA.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100~500
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No507CT2.2.2
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenPurified His-tagged RUVBL1 protein (fragment).
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesRUVBL1, INO80H, NMP238, TIP49, TIP49A, RuvB-like 1, 49kD TATA box-binding protein-interacting protein, 54kD erythrocyte cytosolic protein, INO80 complex subunit H, Nuclear matrix protein 238, Pontin 52, TIP49a, TIP60-associated protein 54-alpha


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