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You are here:Home » Antibodies » Abs to SOCS » Anti -SOCS3 (SOCS3, CIS3, SSI3, Suppressor of cytokine signaling 3, Cytokine-inducible SH2 protein 3, STAT-induced STAT inhibitor 3)

Anti -SOCS3 (SOCS3, CIS3, SSI3, Suppressor of cytokine signaling 3, Cytokine-inducible SH2
protein 3, STAT-induced STAT inhibitor 3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Catalog #031254
ApplicationsSuitable for use in Western Blot, ELISA.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:500~1600
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgM
Clone No532CT13.5.3
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid, crude ascites with 0.09% sodium azide.
PurityAscites
ImmunogenSOCS3 Antibody is generated from mouse immunized with recombinant protein of human SOCS3.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSOCS3, CIS3, SSI3, Suppressor of cytokine signaling 3, Cytokine-inducible SH2 protein 3, STAT-induced STAT inhibitor 3


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