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You are here:Home » Antibodies » Abs to Topoisomerases » Anti -TOP2A (TOP2A, TOP2, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme)

Anti -TOP2A (TOP2A, TOP2, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Catalog #031303
ApplicationsSuitable for use in Western Blot, ELISA.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:500~8000
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No548CT6.1.1
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid, crude ascites with 0.09% sodium azide.
PurityAscites
ImmunogenPurified His-tagged TOP2A protein (fragment).
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesTOP2A, TOP2, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme


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