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You are here:Home » Antibodies » Abs to Neurofilament » Anti -Internexin, alpha (alpha-Internexin, alpha-Inx, INA, Inexa, 66 kD Neurofilament Protein, Neurofilament-66, NF66, NF-66, Neurofilament 5, NEF5)

Anti -Internexin, alpha (alpha-Internexin, alpha-Inx, INA, Inexa, 66 kD Neurofilament
Protein, Neurofilament-66, NF66, NF-66, Neurofilament 5, NEF5)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant B IC IF
a-Internexin is a Class IV intermediate filament subunit. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H, and a-internexin is the major neurofilament protein of developing neurons. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to a-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest. The HGNC name for this protein is INA.
Catalog #031376
ApplicationsSuitable for use in Immunocytochemistry, Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionImmunocytochemistry (ABC): 1:5000
Immunofluorescence: 1:500
Western Blot: 1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No13B826
HostMouse
SourceRat
ConcentrationNot determined
FormSupplied as a liquid.
PuritySupernatant
ImmunogenPurified recombinant rat a-internexin expressed in and purified from E. coli.
SpecificityRecognizes human a-Internexin and with this protein in all mammalian species tested to date.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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