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You are here:Home » Antibodies » Abs to Neurofilament » Anti -Neurofilament L, 68kD (NF-L, NFL, 68kD Neurofilament Protein, NEFL, Neurofilament Light Polypeptide 68kD, NF68, Neurofilament Triplet L Protein)

Anti -Neurofilament L, 68kD (NF-L, NFL, 68kD Neurofilament Protein, NEFL, Neurofilament
Light Polypeptide 68kD, NF68, Neurofilament Triplet L Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IC IF
Neurofilaments can be defined as the intermediate or 10nm diameter filaments found in neuronal cells. They are composed a mixture of subunits which include the neurofilament triplet proteins, NF-L, NF-M and NF-H. Neurofilaments may also include other intermediate filamant subunits such as -internexin, peripherin and in developing neurons nestin and vimentin. Antibodies to neurofilament subunits are very useful cell type markers since the proteins are quite abundant, biochemically stable and found only in neurons. Mutations in the protein coding region of the human NF-L gene appear to cause some forms of Charcot-Marie-Tooth disease (2) The HGNC name for this protein is NEFL.
Catalog #031405
ApplicationsSuitable for use in Immunocytochemistry, Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionImmunocytochemistry (ABC): 1:5000
Immunofluorescence: 1:500-1:1000
Western Blot: 1:20,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourcePorcine
ConcentrationNot determined
FormSupplied as a liquid.
PuritySerum
ImmunogenPorcine intermediate filaments were prepared from spinal cords by the method of Delacourte et al., and this cytoskeletal material was dissolved in 6M urea.
SpecificityRecognizes porcine and rat NF-L.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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