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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -PARK7 (CAP1, Oncogene DJ1, Parkinson Disease (Autosomal Recessive Early Onset) 7, RNA Binding Protein Regulatory Subunit, SP22)

Anti -PARK7 (CAP1, Oncogene DJ1, Parkinson Disease (Autosomal Recessive Early Onset) 7,
RNA Binding Protein Regulatory Subunit, SP22)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IC IF
DJ-1, also known as Park7, is a cytoplasmic protein that belongs to the ThiJ/Pfp1/DJ1 superfamily that function as protein chaperones, catalases, proteases and kinases. DJ-1 was originally cloned as an oncogene that cooperatively transforms cells together with H-ras (1). Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (2). DJ-1 may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death (3-5). Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke (6). The HGNC name for this protein is PARK7.
Catalog #031417
ApplicationsSuitable for use in Immunocytochemistry, Immunofluorescence and Western Blot. On blots 031417 reveals a prominent ~21kD band, and on cells in tissue culture the antibody stains mainly in cytoplasm. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:5000
Western Blot: 1:5000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No13B851
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 10mM sodium azide.
PurityPurified by affinity chromatography.
ImmunogenFull length recombinant human DJ-1 expressed in and purified from E. coli.
SpecificityRecognizes DJ-1 from human, bovine and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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