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031936 Rabbit Anti-AP1G2, NT (AP1G2, AP-1 complex subunit gamma-like 2, Gamma2-adaptin)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
O75843; NP_003908.1
Gene ID
8906
Gene #
AP1G2
Shipping Temp
Blue Ice
Storage Temp
-20°C
AP1G2, AP-1 complex subunit gamma-like 2, Gamma2-adaptin

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
AP1G2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human AP1G2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Doring, T., et al. Biochim. Biophys. Acta 1803(11):1252-1264(2010)|Rost, M., et al. J. Biol. Chem. 283(46):32119-32130(2008)|Lambert, C., et al. J. Virol. 81(17):9050-9060(2007)|Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)|Mattera, R., et al. J. Biol. Chem. 279(9):8018-8028(2004)
USBio References
No references available
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