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031996 Rabbit Anti-APP, ID (APP, A4, AD1, Amyloid beta A4 protein, ABPP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, N-APP, Soluble APP-alpha, Soluble APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, Gamma-CTF(50), C31)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P05067
Isotype
IgG
Grade
Affinity Purified
Applications
E IF IHC WB
Crossreactivity
Hu
Accession #
NP_958816.1
Gene ID
351
Gene #
APP
Shipping Temp
Blue Ice
Storage Temp
-20°C
APP, A4, AD1, Amyloid beta A4 protein, ABPP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, N-APP, Soluble APP-alpha, Soluble APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, Gamma-CTF(50), C31

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunofluorescence: 1:10-50 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Dahse, K., et al. J. Mol. Biol. 403(4):643-659(2010)|Hare, J. Biochem. Biophys. Res. Commun. 401(2):219-224(2010)|Vossel, K.A., et al. Science 330 (6001), 198 (2010) :|Singh, T.D., et al. FEBS Lett. 584(18):3936-3942(2010)|Crews, L., et al. J. Neurosci. 30(37):12252-12262(2010)
USBio References
No references available
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