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032023 Rabbit Anti-ARFGAP3, CT (ARFGAP3, ARFGAP1, ADP-ribosylation factor GTPase-activating protein 3)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9NP61
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001135765.1; NP_055385.3
Gene ID
26286
Gene #
ARFGAP3
Shipping Temp
Blue Ice
Storage Temp
-20°C
ARFGAP3, ARFGAP1, ADP-ribosylation factor GTPase-activating protein 3

The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
ARFGAP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-473 amino acids from the C-terminal region of human ARFGAP3.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Saitoh, A., et al. J. Biol. Chem. 284(20):13948-13957(2009)|Weimer, C., et al. J. Cell Biol. 183(4):725-735(2008)|Frigerio, G., et al. Traffic 8(11):1644-1655(2007)|Olsen, J.V., et al. Cell 127(3):635-648(2006)
USBio References
No references available
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