Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -AXIN2, CT (AXIN2, Axin-2, Axin-like protein, Axis inhibition protein 2, Conductin) (PE)

Anti -AXIN2, CT (AXIN2, Axin-2, Axin-like protein, Axis inhibition protein 2, Conductin)
(PE)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH FC
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Catalog #032342-PE
ApplicationsSuitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, FLISA
Recommended DilutionFLISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).
PurityPurified by Protein A affinity chromatography.
ImmunogenAXIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 823-853 amino acids from the C-terminal region of human AXIN2.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAXIN2, Axin-2, Axin-like protein, Axis inhibition protein 2, Conductin


External Links