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You are here:Home » Antibodies » Abs to KIAA, orf » Anti -BBS10, CT (BBS10, C12orf58, Bardet-Biedl syndrome 10 protein)

Anti -BBS10, CT (BBS10, C12orf58, Bardet-Biedl syndrome 10 protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B FC
BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.
Catalog #032438
ApplicationsSuitable for use in Western Blot, Flow Cytometry, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenBBS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acids 520-550 from the C-terminal region of human BBS10.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesBBS10, C12orf58, Bardet-Biedl syndrome 10 protein


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