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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -BMI, ID (Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51)

Anti -BMI, ID (Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING
finger protein 51, BMI1, PCGF4, RNF51)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.
Catalog #032538
ApplicationsSuitable for use in Immunohistochemistry, ELISA
Recommended DilutionELISA: 1:1,000
Immunohistochemistry: 1:50-100
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenBMI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128~158 amino acids from the central region of human BMI.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPolycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51


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