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Specifications

Clone Host Grade Applications Polyclonal Rabbit Purified E B IH FC IF

CAV1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex.
Catalog #	033227
Applications	Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry
Recommended Dilution	ELISA: 1:1,000
	Western Blot: 1:100-500
	Immunohistochemistry: 1:50-100
	Flow Cytometry: 1:10-50
	Immunofluorescence: 1:10-50
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	0.25mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity	Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Immunogen	CAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acid 50-80 from the Central region of human CAV1.
Specificity	Human, mouse
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	CAV1, CAV, Caveolin-1