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033549 Rabbit Anti-CD8B, NT (CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain, CD8b)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P10966
Isotype
IgG
Grade
Affinity Purified
Applications
E FC WB
Crossreactivity
Hu
Gene ID
926
Gene #
CD8B
Shipping Temp
Blue Ice
Storage Temp
-20°C
CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain, CD8b

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.

Applications
Suitable for use in Western Blot, Indirect Flow Cytometry and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 64-92 in the N-terminal region of human CD8B, UniProt Accession #P10966.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Purity
Purified by Protein A affinity chromatography
Specificity
Recognizes human CD8B.
References
1. Nakayama,K., J. Immunol. 148 (6), 1919-1927 (1992). 2. Terry,L.A., Tissue Antigens 35 (2), 82-91 (1990). 3. Parnes,J.R.,Adv. Immunol. 44, 265-311 (1989)
USBio References
No references available
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