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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -CDKN1A, CT (Cyclin-dependent kinase inhibitor 1,CDKN1A,CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1) (Biotin)

Anti -CDKN1A, CT (Cyclin-dependent kinase inhibitor 1,CDKN1A,CAP20, CDKN1, CIP1, MDA6,
PIC1, SDI1, WAF1) (Biotin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
Catalog #033701-Biotin
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.
PurityPurified by Protein A affinity chromatography.
ImmunogenCDKN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-146 amino acids from the C-terminal region of human CDKN1A.
SpecificityHuman, mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCyclin-dependent kinase inhibitor 1,CDKN1A,CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1


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