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034279 Rabbit Anti-CSHL1, CT (CSHL1, CSHP1, CSL, Chorionic somatomammotropin hormone-like 1, Lactogen-like)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q14406
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
NP_072103.1
Gene ID
1444
Gene #
CSHL1
Shipping Temp
Blue Ice
Storage Temp
-20°C
CSHL1, CSHP1, CSL, Chorionic somatomammotropin hormone-like 1, Lactogen-like

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified.

Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
CSHL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-152 amino acids from the C-terminal region of human CSHL1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Bailey, S.D., et al. Diabetes Care (2010) In press :|Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)|Misra-Press, A., et al. J. Biol. Chem. 269(37):23220-23229(1994)|MacLeod, J.N., et al. J. Biol. Chem. 267(20):14219-14226(1992)|Vnencak-Jones, C.L., et al. Science 250(4988):1745-1748(1990)
USBio References
No references available
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