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034421 Rabbit Anti-CYP11B1, NT (CYP11B1, S11BH, Cytochrome P450 11B1, mitochondrial, CYPXIB1, Cytochrome P-450c11, Steroid 11-beta-hydroxylase)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P15538
Isotype
IgG
Grade
Purified
Applications
E FC IHC WB
Crossreactivity
Hu
Gene ID
1584
Gene #
CYP11B1
Shipping Temp
Blue Ice
Storage Temp
-20°C
CYP11B1, S11BH, Cytochrome P450 11B1, mitochondrial, CYPXIB1, Cytochrome P-450c11, Steroid 11-beta-hydroxylase

CYP11B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Indirect Flow Cytometry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:50-100 Immunohistochemistry: 1:50-100 Indirect Flow Cytometry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
CYP11B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23~52 amino acids from the N-terminal region of human CYP11B1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Recognizes human CYP11B1
References
Helmberg,A., et.al., J. Clin. Endocrinol. Metab. 75 (5), 1278-1281 (1992) Nelson,D.R., et.al., Pharmacogenetics 14 (1), 1-18 (2004)
USBio References
No references available
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