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You are here:Home » Antibodies » Antibodies-Carbohydrates, Glycoproteins » Anti -DAG1, CT (DAG1, Dystroglycan, Dystrophin-associated glycoprotein 1, Alpha-dystroglycan, Beta-dystroglycan)

Anti -DAG1, CT (DAG1, Dystroglycan, Dystrophin-associated glycoprotein 1,
Alpha-dystroglycan, Beta-dystroglycan)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
Catalog #034461
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested.
Recommended DilutionsWestern Blot: 1:1000
Immunohistochemistry (FFPE): 1:10-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
ConcentrationAs Reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
PurityPurified by Protein A affinity chromatography
ImmunogenKLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 718-747 in the C-terminal region of human DAG1, UniProt Accession #NP_001171107.1; NP_001171111.1; NP_004384.4; Q14118.
SpecificityRecognizes human DAG1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDAG1, Dystroglycan, Dystrophin-associated glycoprotein 1, Alpha-dystroglycan, Beta-dystroglycan

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