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034961 Rabbit Anti-EGFR, CT (S1026) (EGFR, ERBB, ERBB1, HER1, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P00533
Isotype
IgG
Grade
Affinity Purified
Applications
E FC IHC WB
Crossreactivity
Hu
Accession #
NP_958440.1; NP_005219.2
Gene ID
1956
Gene #
EGFR
Shipping Temp
Blue Ice
Storage Temp
-20°C
EGFR, ERBB, ERBB1, HER1, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Indirect Flow Cytometry and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000 Immunohistochemistry: 1:50-1:100 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1004-1033 in the C-terminal region of human EGFR, UniProt Accession #P00533. Epitope: Residues surrounding Serine-1026.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human EGFR.
References
Perez, C.A., et al. J. Urol. 183(5):2062-2069(2010) Koumakpayi, I.H., et al. Br. J. Cancer 102(7):1163-1173(2010) Cortot, A.B., et al. Cancer (2010) In press :Lee, Y.J., et al. J. Cancer Res. Clin. Oncol. (2010) In press : Kawahara, A., et al. Hum. Pathol. (2010) In press : Wu, S.L., et al. Mol. Cell Proteomics 5(9):1610-1627(2006) Wu, S.L., et al. J. Proteome Res. 4(4):1155-1170(2005) Abe, Y., et al. J. Biol. Chem. 273(18):11150-11157(1998) Li, W., et al. Mol. Cell. Biol. 12(12):5824-5833(1992) Krieg, J., et al. Biol. Chem. 267(27):19258-19265(1992) Lowenstein, E.J., et al. Cell 70(3):431-442(1992) Chi, D.D., et al. Hum. Mol. Genet. 1 (2), 135 (1992) : Countaway, J.L., et al. J. Biol. Chem. 267(2):1129-1140(1992)
USBio References
No references available
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