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You are here:Home » Antibodies » Abs to Kelch-like Proteins » Anti -ENC1, CT (ENC1, KLHL37, NRPB, PIG10, Ectoderm-neural cortex protein 1, Kelch-like protein 37, Nuclear matrix protein NRP/B, p53-induced gene 10 protein) (FITC)

Anti -ENC1, CT (ENC1, KLHL37, NRPB, PIG10, Ectoderm-neural cortex protein 1, Kelch-like
protein 37, Nuclear matrix protein NRP/B, p53-induced gene 10 protein) (FITC)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) [PubMed 9305847] used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) [PubMed 9305847] termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.
Catalog #035070-FITC
ApplicationsSuitable for use in Western Blot, FLISA
Recommended DilutionFLISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze FITC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to FITC.
PurityPurified by Protein A affinity chromatography.
ImmunogenENC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-423 amino acids from the C-terminal region of human ENC1.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesENC1, KLHL37, NRPB, PIG10, Ectoderm-neural cortex protein 1, Kelch-like protein 37, Nuclear matrix protein NRP/B, p53-induced gene 10 protein


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