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035132 Rabbit Anti-EPOR, ID (EPOR, Erythropoietin receptor)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P19235
Isotype
IgG
Grade
Affinity Purified
Applications
E FC IF WB
Crossreactivity
Hu
Accession #
NP_000112.1
Gene ID
2057
Gene #
EPOR
Shipping Temp
Blue Ice
Storage Temp
-20°C
EPOR, Erythropoietin receptor

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

Applications
Suitable for use in Western Blot, Immunofluorescence, Indirect Flow Cytometry and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Flow Cytometry (Indirect): 1:10-1:50 Immunofluorescence: 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 329-357 in the central region of human EPOR
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human EPOR.
References
1. Lim, A.C., et al. Biochemistry 49(18):3797-3804 (2010). 2. Perrotta, S., et al. PLoS ONE 5 (8), E12015 (2010). 3. Khankin, E.V., et al. PLoS ONE 5 (2), E9246 (2010). 4. Wincewicz, A., et al. Folia Histochem. Cytobiol. 47(3):425-430 (2009). 5. Ketteler, R., et al. J. Biol. Chem. 278(4):2654-2660 (2003)
USBio References
No references available
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