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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -FZR1, NT (FZR1, CDH1, FYR, FZR, KIAA1242, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog)

Anti -FZR1, NT (FZR1, CDH1, FYR, FZR, KIAA1242, Fizzy-related protein homolog, CDC20-like
protein 1, Cdh1/Hct1 homolog)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Catalog #035824
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenFZR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human FZR1.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesFZR1, CDH1, FYR, FZR, KIAA1242, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog


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