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036215 Rabbit Anti-GPR109B, NT (HCAR3, GPR109B, HCA3, HM74B, NIACR2, Hydroxycarboxylic acid receptor 3, Nicotinic acid receptor 2, G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, Niacin receptor 2)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P49019
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu
Accession #
NP_006009.2
Gene ID
8843
Gene #
GPR109B
Shipping Temp
Blue Ice
Storage Temp
-20°C
HCAR3, GPR109B, HCA3, HM74B, NIACR2, Hydroxycarboxylic acid receptor 3, Nicotinic acid receptor 2, G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, Niacin receptor 2

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.

Applications
Suitable for use in Western Blot. Other applications have not been tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa71-99 in the N-terminal region of human GPR109B.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human GPR109B.
References
1. Bailey, S.D., et al. Diabetes Care (2010). 2. Mandrika, I., et al. Biochem. Biophys. Res. Commun. 395(2):281-287(2010). 3. Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). 4. Jeninga, E.H., et al. J. Biol. Chem. 284(39): 26385-26393(2009). 5. Ahmed, K., et al. J. Biol. Chem. 284(33): 21928-21933(2009).
USBio References
No references available
Conjugates
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