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You are here:Home » Antibodies » Abs to Amino Acids » Anti -GREMLIN, CT (Grem1, Cktsf1b1, Drm, Gremlin-1, Cysteine knot superfamily 1, BMP antagonist 1, Down-regulated in Mos-transformed cells protein)

Anti -GREMLIN, CT (Grem1, Cktsf1b1, Drm, Gremlin-1, Cysteine knot superfamily 1, BMP
antagonist 1, Down-regulated in Mos-transformed cells protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B IH
GREMLIN is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.
Catalog #036285
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested.
Recommended DilutionWestern Blot: 1:1000
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Ammonium Sulfate Precipitation.
ImmunogenKLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 147-175 in the C-terminal region of human Gremlin, UniProt Accession #O70326. Species sequence homology: rat
SpecificityRecognizes human Gremlin. Species crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesGrem1, Cktsf1b1, Drm, Gremlin-1, Cysteine knot superfamily 1, BMP antagonist 1, Down-regulated in Mos-transformed cells protein


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