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You are here:Home » Antibodies » Abs to Enzymes, Heparanase » Anti -Heparanase, NT (Heparanase [Precursor], Heparanase-1, Hpa1, Endo-glucoronidase, HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1,) (PE)

Anti -Heparanase, NT (Heparanase [Precursor], Heparanase-1, Hpa1, Endo-glucoronidase,
HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1,) (PE)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
FUNCTION: Heparanase, a cell surface and extracellular matrix-degrading enzyme cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. This enzyme is also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti-cancer therapies. ENZYME REGULATION: Inhibited by EDTA, laminarin sulfate and, to a lower extent, by heparin and sulfamin and activated by calcium and magnesium. TISSUE SPECIFICITY: Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues.
Catalog #036509-PE
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot1:250-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).
PurityPurified by Protein G affinity chromatography.
ImmunogenHeparanase antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Heparanase.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesHeparanase [Precursor], Heparanase-1, Hpa1, Endo-glucoronidase, HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1,


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