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036843-APC Rabbit Anti-HVCN1, NT (HVCN1, VSOP, Voltage-gated hydrogen channel 1, Hydrogen voltage-gated channel 1, Voltage sensor domain-only protein) (APC)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q96D96
Conjugate
APC
Isotype
IgG
Grade
Affinity Purified
Applications
FLISA WB
Crossreactivity
Hu
Gene ID
84329
Gene #
HVCN1
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
HVCN1, VSOP, Voltage-gated hydrogen channel 1, Hydrogen voltage-gated channel 1, Voltage sensor domain-only protein

HVCN1 is a voltage-gated proton channel highly expressed in immune tissues. Channels like HVCN1 mediate the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing.

Applications
Suitable for use in Western Blot and FLISA. Other potential application, though not tested is Direct Flow Cytometry. Other applications have not been tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1-30 in the N-terminal region of human HVCN1.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human HVCN1.
References
1. Musset, B., et al. J. Biol. Chem. 285(8):5117-5121(2010) 2. Lishko, P.V., et al. Cell 140(3):327-337(2010) 3. Sakata, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):2313-2318(2010)
USBio References
No references available
Conjugates
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