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037108 Rabbit Anti-IRGM, CT (IRGM, IFI1, IRGM1, LRG47, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
A1A4Y4; NP_001139277.1
Gene ID
345611
Gene #
IRGM
Shipping Temp
Blue Ice
Storage Temp
-20°C
IRGM, IFI1, IRGM1, LRG47, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog

This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.

Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
IRGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-186 amino acids from the C-terminal region of human IRGM.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Che, N., et al. Clin. Chim. Acta 411 (21-22), 1645-1649 (2010) :|Wolfkamp, S.C., et al. Eur J Gastroenterol Hepatol 22(8):933-937(2010)|Latiano, A., et al. Inflamm. Bowel Dis. 16(7):1108-1117(2010)|Prescott, N.J., et al. Hum. Mol. Genet. 19(9):1828-1839(2010)|Bekpen, C., et al. PLoS Genet. 5 (3), E1000403 (2009) :
USBio References
No references available
Conjugates
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