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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -ITCH, ID (ITCH, E3 ubiquitin-protein ligase Itchy homolog, Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1)

Anti -ITCH, ID (ITCH, E3 ubiquitin-protein ligase Itchy homolog, Atrophin-1-interacting
protein 4, NFE2-associated polypeptide 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Catalog #037130
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-536 amino acids from the Central region of human ITCH.
SpecificityMouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesITCH, E3 ubiquitin-protein ligase Itchy homolog, Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1


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