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You are here:Home » Antibodies » Abs to Transmembrane Proteins » Anti -ITM2C, NT (ITM2C, BRI3, Integral membrane protein 2C, Cerebral protein 14, Transmembrane protein BRI3, CT-BRI3)

Anti -ITM2C, NT (ITM2C, BRI3, Integral membrane protein 2C, Cerebral protein 14,
Transmembrane protein BRI3, CT-BRI3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
Catalog #037160
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenITM2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human ITM2C.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesITM2C, BRI3, Integral membrane protein 2C, Cerebral protein 14, Transmembrane protein BRI3, CT-BRI3


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