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037214 Rabbit Anti-JPH2, CT (JPH2, JP2, Junctophilin-2, Junctophilin type 2)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9BR39
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_065166.2; NP_787109.2
Gene ID
57158
Gene #
JPH2
Shipping Temp
Blue Ice
Storage Temp
-20°C
JPH2, JP2, Junctophilin-2, Junctophilin type 2

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
JPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-643 amino acids from the C-terminal region of human JPH2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Woo, J.S., et al. Biochem. J. 427(1):125-134(2010)|Yamazaki, D., et al. Pharmacol. Ther. 121(3):265-272(2009)|Landstrom, A.P., et al. J. Mol. Cell. Cardiol. 42(6):1026-1035(2007)|Matsushita, Y., et al. J. Hum. Genet. 52(6):543-548(2007)
USBio References
No references available
Conjugates
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