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037321 Rabbit Anti-KCNJ10, ID (KCNJ10, ATP-sensitive inward rectifier potassium channel 10, ATP-dependent inwardly rectifying potassium channel Kir4.1, Inward rectifier K(+) channel Kir1.2, Potassium channel, inwardly rectifying subfamily J member 10)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P78508
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_002232.2
Gene ID
3766
Gene #
KCNJ10
Shipping Temp
Blue Ice
Storage Temp
-20°C
KCNJ10, ATP-sensitive inward rectifier potassium channel 10, ATP-dependent inwardly rectifying potassium channel Kir4.1, Inward rectifier K(+) channel Kir1.2, Potassium channel, inwardly rectifying subfamily J member 10

This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.

Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 203-230 in the Central region of human KCNJ10, UniProt Accession #P78508. Species Sequence Homology: mouse and rat
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human KCNJ10 at ~43kD.
References
1. Jonard, L., et al. Int. J. Pediatr. Otorhinolaryngol. 74(9):1049-1053(2010). 2. Reichold, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14490-14495(2010). 3. Heuser, K., et al. Epilepsy Res. 88(1):55-64(2010). 4. Pawelczyk, M., et al. Ann. Hum. Genet. 73 (PT 4), 411-421 (2009). 5. Yang, T., et al. Am. J. Hum. Genet. 84(5):651-657(2009)
USBio References
No references available
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