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038049 Rabbit Anti-M6PR, CT (M6PR, MPR46, MPRD, Cation-dependent mannose-6-phosphate receptor, 46kD mannose 6-phosphate receptor)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P20645
Isotype
IgG
Grade
Purified
Applications
E FC IF WB
Crossreactivity
Hu
Accession #
NP_002346.1
Gene ID
4074
Gene #
M6PR
Shipping Temp
Blue Ice
Storage Temp
-20°C
M6PR, MPR46, MPRD, Cation-dependent mannose-6-phosphate receptor, 46kD mannose 6-phosphate receptor

The protein encoded by this gene is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane.

Applications
Suitable for use in Western Blot, Immunofluorescence, Indirect Flow Cytometry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:50-100 Indirect Flow Cytometry: 1:10-50 Immunofluorescence: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
M6PR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-268 amino acids from the C-terminal region of human M6PR.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
References
Bosker, F.J., et al. Mol. Psychiatry (2010) In press :|Op den Brouw, M.L., et al. Virology 393(1):84-90(2009)|Schimanski, L.M., et al. Blood Cells Mol. Dis. 43(2):180-193(2009)|Rodriguez-Gabin, A.G., et al. Exp. Cell Res. 315(13):2215-2230(2009)|Xaplanteri, P., et al. Eur. J. Immunol. 39(3):730-740(2009)
USBio References
No references available
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