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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -MARCH1, ID (MARCH1, RNF171, E3 ubiquitin-protein ligase MARCH1, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, RING finger protein 171)

Anti -MARCH1, ID (MARCH1, RNF171, E3 ubiquitin-protein ligase MARCH1, Membrane-associated
RING finger protein 1, Membrane-associated RING-CH protein I, RING finger protein 171)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).
Catalog #038192
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenMARCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the Central region of human MARCH1.
SpecificityMouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMARCH1, RNF171, E3 ubiquitin-protein ligase MARCH1, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, RING finger protein 171


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