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You are here:Home » Antibodies » Abs to Cancer Markers, Leukemia » Anti -MLF1, CT (MLF1, Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1)

Anti -MLF1, CT (MLF1, Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH FC
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Catalog #038463
ApplicationsSuitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50
Immunohistochemistry: 1:10-50
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenMLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222~252 amino acids from the C-terminal region of human MLF1.
SpecificityHuman, mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMLF1, Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1


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