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038583 Rabbit Anti-MRGBP, ID (MRGBP, C20orf20, MRG-binding protein)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9NV56
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_060740.1
Gene ID
55257
Gene #
MRGBP
Shipping Temp
Blue Ice
Storage Temp
-20°C
MRGBP, C20orf20, MRG-binding protein

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
MRGBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-75 amino acids from the Central region of human MRGBP.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Yamaguchi, K., et al. Br. J. Cancer 102(2):325-331(2010)|Cai, Y., et al. J. Biol. Chem. 280(14):13665-13670(2005)|Cai, Y., et al. J. Biol. Chem. 278(44):42733-42736(2003)|Deloukas, P., et al. Nature 414(6866):865-871(2001)
USBio References
No references available
Conjugates
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