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038715 Rabbit Anti-MYBPC3, NT (MYBPC3, Myosin-binding protein C, cardiac-type, C-protein, cardiac muscle isoform)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q14896
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu Mo Rt
Accession #
NP_000247.2
Gene ID
4607
Gene #
MYBPC3
Shipping Temp
Blue Ice
Storage Temp
-20°C
MYBPC3, Myosin-binding protein C, cardiac-type, C-protein, cardiac muscle isoform

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

Applications
Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000-1:2000 Immunohistochemistry (FFPE): 1:25 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 189-218 in the N-terminal region of human MYBPC3. Swiss/UniProt Accession: Q14896.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human MYBPC3. Species Crossreactivity: mouse, rat
References
1. Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) : 2. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) 3. Millat, G., et al. Eur J Med Genet 53(5):261-267(2010) 4. Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010) 5. Brion, M., et al. Ann. Clin. Lab. Sci. 40(3):285-289(2010)
USBio References
No references available
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