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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -NEDD4L, ID (NEDD4L, KIAA0439, NEDL3, E3 ubiquitin-protein ligase NEDD4-like, NEDD4.2, Nedd4-2)

Anti -NEDD4L, ID (NEDD4L, KIAA0439, NEDL3, E3 ubiquitin-protein ligase NEDD4-like,
NEDD4.2, Nedd4-2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK.
Catalog #038877
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenNEDD4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-604 amino acids from the Central region of human NEDD4L.
SpecificityMouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesNEDD4L, KIAA0439, NEDL3, E3 ubiquitin-protein ligase NEDD4-like, NEDD4.2, Nedd4-2


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