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038892 Rabbit Anti-NEO1, ID (NEO1, IGDCC2, NGN, Neogenin, Immunoglobulin superfamily DCC subclass member 2)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q92859
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu Mo
Accession #
NP_002490.2
Gene ID
4756
Gene #
NEO1
Shipping Temp
Blue Ice
Storage Temp
-20°C
NEO1, IGDCC2, NGN, Neogenin, Immunoglobulin superfamily DCC subclass member 2

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq].

Applications
Suitable for use in Western Blot and ELISA. Other applications not tested.
Recommended Dilution
Western Blot: 1:100-1:500 Optimal dilutions to be determined by the reasearcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 657-685 in the Central region of human NEO1. Species sequence homology: rat
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human NEO1. Species Crossreactivity: mouse
References
1. Bradford, D., et al. J. Comp. Neurol. 518(16):3237-3253(2010) 2. Davila, S., et al. Genes Immun. 11(3):232-238(2010) 3. Zhang, A.S., et al. J. Biol. Chem. 284(34):22580-22589(2009) 4. Fujita, Y., et al. Cell Death Differ. 15(10):1593-1608(2008) 5. Zhang, A.S., et al. J. Biol. Chem. 283(25):17494-17502(2008).
USBio References
No references available
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