Anti -NFKBIA (Ser32) (NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha,
I-kappa-B-alpha, Major histocompatibility complex enhancer-binding protein MAD3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH FC IF |
|
| NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). | | | Catalog # | 038939 | | Applications | Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:100-500 | | Immunohistochemistry: 1:50-100 | | Flow Cytometry: 1:10-50 | | Immunofluorescence: 1:10-50 | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | 0.25mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | NFKBIA (Ser32) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18~48 amino acids from the S32 region of human NFKBIA. | | Specificity | Human, hamster, mouse | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, Major histocompatibility complex enhancer-binding protein MAD3 |
External Links
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