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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -NFKBIA, phosphorylated (Ser32) (NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, Major histocompatibility complex enhancer-binding protein MAD3)

Anti -NFKBIA, phosphorylated (Ser32) (NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor
alpha, I-kappa-B-alpha, Major histocompatibility complex enhancer-binding protein MAD3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.
Catalog #038940
ApplicationsSuitable for use in Dot Blot, ELISA
Recommended DilutionELISA: 1:1,000
Dot blot 1:500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenPhospho-NFKBIA (Ser32) antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between amino acids 20-50 surrounding S32 of human NFKBIA.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesNFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, Major histocompatibility complex enhancer-binding protein MAD3


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