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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -NRG3, ID (NRG3, Pro-neuregulin-3, membrane-bound isoform, Neuregulin-3)

Anti -NRG3, ID (NRG3, Pro-neuregulin-3, membrane-bound isoform, Neuregulin-3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.
Catalog #039148
ApplicationsSuitable for use in Immunohistochemistry, ELISA
Recommended DilutionELISA: 1:1,000
Immunohistochemistry: 1:50-100
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenNRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human NRG3.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesNRG3, Pro-neuregulin-3, membrane-bound isoform, Neuregulin-3


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