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039164 Rabbit Anti-NSMAF, NT (NSMAF, FAN, Protein FAN, Factor associated with neutral sphingomyelinase activation)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Mouse
Swiss Prot
Q92636
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu Mo
Accession #
NP_003571.2; NP_001138244.1
Gene ID
8439
Gene #
NSMAF
Shipping Temp
Blue Ice
Storage Temp
-20°C
NSMAF, FAN, Protein FAN, Factor associated with neutral sphingomyelinase activation

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.

Applications
Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 28-57 in the N-terminal region of human NSMAF.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes mouse NSMAF. Species Crossreactivity: human.
References
1. Bailey, S.D., et al. Diabetes Care (2010). 2. Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009). 3. Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). 4. Clarke, C.J., et al. Mol. Pharmacol. 74(4):1022-1032(2008). 5. Kolzer, M., et al. Biol. Chem. 385(12):1193-1195(2004)
USBio References
No references available
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