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You are here:Home » Antibodies » Abs to Enzymes, Polymerase » Anti -POLR3B, NT (POLR3B, DNA-directed RNA polymerase III subunit RPC2, C128, DNA-directed RNA polymerase III 127.6kD polypeptide, DNA-directed RNA polymerase III subunit B)

Anti -POLR3B, NT (POLR3B, DNA-directed RNA polymerase III subunit RPC2, C128, DNA-directed
RNA polymerase III 127.6kD polypeptide, DNA-directed RNA polymerase III subunit B)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.
Catalog #040265
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenPOLR3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-359 amino acids from the N-terminal region of human POLR3B.
SpecificityMouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPOLR3B, DNA-directed RNA polymerase III subunit RPC2, C128, DNA-directed RNA polymerase III 127.6kD polypeptide, DNA-directed RNA polymerase III subunit B


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