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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -PPM1A (PPM1A, PPPM1A, Protein phosphatase 1A, Protein phosphatase 2C isoform alpha, Protein phosphatase IA)

Anti -PPM1A (PPM1A, PPPM1A, Protein phosphatase 1A, Protein phosphatase 2C isoform alpha,
Protein phosphatase IA)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Catalog #040323
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenPPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from human PPM1A.
SpecificityHuman
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPPM1A, PPPM1A, Protein phosphatase 1A, Protein phosphatase 2C isoform alpha, Protein phosphatase IA


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