Anti -RIG-I, CT (I790) (Probable ATP-dependent RNA helicase DDX58, DEAD-box protein 58,
Retinoic acid-inducible gene 1 protein, RIG-1, RIG-I, DDX58,)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
E |
|
| DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, RIG-I triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). This protein is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. | | | Catalog # | 041050 | | Applications | Suitable for use in ELISA | | Recommended Dilution | ELISA: 1:1,000 | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | 0.25mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. | | Purity | Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS. | | Immunogen | RIG-I antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 783~812 amino acids from the C-terminal region of human RIG-I. | | Specificity | Human | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Probable ATP-dependent RNA helicase DDX58, DEAD-box protein 58, Retinoic acid-inducible gene 1 protein, RIG-1, RIG-I, DDX58, |
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